Subjects from around the world easily use any of the communication tools to enter data for diaries, registries and outcome measures. When scheduled entries are not made in the database, the Kronos system reminds users to record the anticipated entry. Inter-rater reliability is improved when all subjects hear and respond to identical prompts.

Kronos recognizes the importance of reliable, globally accessible applications for Investigational Sites. Based on these values, Investigators enjoy the flexibility of site specific communication interfaces, streamlined to meet protocol requirement in the language of choice.

Kronos coordinates its functionality with other study vendors, ensuring a seamless interaction for data sharing.

Maximize staff utility by managing study functions using any one or all of the Kronos processes.

Optimize data collection, processing and dissemination by using information to inform future tasks.

From subject to sponsor, study participants input and access data through Kronos interfaces.

The most widely used communication tool, the telephone, enables toll-free global interactions with the Kronos database.

Information can be transmitted in real-time or collected and transmitted on a scheduled basis using these convenient devices.

Most frequently requested by other vendors, information historically delivered via fax is available via e-mail.

Real-time data available on-line makes study progress reporting accessible by all study participants.

Historically the favored communication vehicle, Kronos oversees all fax and guarantees delivery.

Each study is unique not only in terms of the research being performed but also in terms of the ways the participants communicate with each other. Kronos supports communication among the participants using devices from the traditional telephone to the real-time Internet. Any combination of these devices can be used by the different participants. Kronos is the unifying agent, ensuring that all participants enter and receive the information that is critical for a successful study.

Kronos data collection is the framework upon which study processes are optimized. Coordination of tasks enhances continuous adaptation and innovation for speedy database lock.

Transparent study drug management according to requirements; typical is the use of the treatment allocation platform for JIT distribution, eliminating the need to distribute unnecessary drug. Inventory supply may also be managed by maintaining a threshold supply at the site. Faxes or Web confirmation of shipment and receipt of supplies are issued.

Continuous on-line access tiered for real-time trial data that enables oversight and analysis; on-demand and scheduled reports of data, in a case-by-case format, or summarized for analysis. Summaries and analysis of data, during a trial, produce trial evaluation tools, including accruals and audits of investigational site activity. Real-time reporting through a secure web site or FTP site. Additional reports delivered via e-mail, fax or CD.

Investigational sites call a toll-free number to access the IVR, or Web-page to input subject data. Information about screening is captured and reported for randomization eligibility. Centralized randomization affords the use of algorithms for stratification, balancing and adaptive techniques. Study drug is assigned. Milestones may be recorded and reported for purposes of disbursements. All entries confirmed via fax or e-mail.

Automated data collection and management for diary studies, outcomes, satisfaction and quality of life screening and monitoring. Gather data directly from subjects through IVR or Web-page. Increase reliability of data by improving timeliness of responses. Notification reminders sent for failed responders, improving response rate. Scalable databases capture input from a few hundred to thousands of users.

Kronos designs its own innovative systems and maintains control over the systems facilitating modification and data cleaning. Continuous development incorporates leading edge research technology.